3dpredict/Ab is a Software-as-a-Service (SaaS) platform by Discngine designed to streamline antibody development efforts with unique in silico methods based on dynamic structural ensembles, eliminating single-structure bias.
It empowers antibody designers, modelers, and engineers with a modern tool to quickly identify the best candidate antibodies for developability and liabilities, reducing production issues and costs.
The platform is cloud-based, which allows it to support large-scale screenings, simplify complex workflows, integrate with existing applications and speed up your lead optimization phase.
Successfully prioritize antibodies to accelerate your lead optimization phase
Ensemble-based predictions at your fingertips
Accurate antibody developability insights from Ensemble-based predictions accounting for conformational pH-dependence and flexibility
User-friendly platform built for efficient discoveries
Intuitive web-based interface adapted to both small and big antibody discovery groups in pharma and biotech
Instant access to focus on science, not IT hassle
Immediately available on the advanced cloud environment with the highest levels of data safety and security without any deployment efforts
Enhance your discovery workflows with high-quality predictions
3D Model building & Calculations setup
Simply upload a series of sequences or structures via UI or your applications via API (fasta, xlsx, pdb, alphafold)
Benefit from broad format compatibility (Fv, scFv, VHH, Fabs, bispecifics, and custom structures)
Set up the calculations for conformational sampling and pH
Developability & Liability Screening
Leverage high-performant proprietary algorithm based on four determined rules for therapeutic antibody profiling against clinical-stage antibodies (Thorsteinson et al; mAbs 13 (2023) 219-235)
Quickly screen from a few to tens of thousands of antibody candidates (up to 30k Fv ensemble calculations /day)
Spot detrimental liabilities early in the screening process
Retrive high-quality properties in minutes to quickly identify the best candidates
Analysis & Optimization
Easily visualize and compare physico-chemical properties of each antibody with standardized patch maps for quick surface patch comparisons
Spot outliers compared to your reference space with easy to spot & customizeable coloring rules and different plotting options
Analyze residues and related liabilities for prioritization, and map the residues back to the 3D model to decide on the next optimization move
Export ensemble properties for training machine learning models on high-quality data.
Cloud technology
We offer secure application and data hosting on the Discngine Cloud Infrastructure, fully managed by our experts.
Data protection
Discngine complies with ISO 27001 information security standards, ensuring the highest security in software development and protection of research data.
Integration
The powerful REST API allows seamless integration with the existing in-house IT ecosystem to enhance commonly used tools with complementary insights.
