As an official KNIME Partner, we at Discngine are extremely happy that the work accomplished with our client CENTOGENE resulted in a KNIME Success Story. Read more to discover the story behind the project!

Cloud environment can bring a lot of benefits, to research-driven organizations, but shifting from an on-premises (local) to a Cloud environment can be challenging and sometimes scary. This article will outline an example of a French Biotech Startup that migrated its scientific software applications toolset to the Cloud and reveal the real-life advantages of this migration that exceeded expectations.

Over the last two years, we observed a significant mindset change in life science research organizations towards the cloud technologies landscape. Less fear and skepticism, a better understanding of the capabilities, and rising expectations. Nevertheless, some obstacles specific to our business remain.
In this article, we explore five of the most common obstacles to Cloud shift for life science R&D and how to overcome them.

The purpose of this article is to illustrate how to apply some of 3decision’s features in scientific research. For this use case, the 3decision Subpocket Similarity Search is used to suggest modifications for the optimization of a small- molecule PROTAC. The Protein-Ligand interaction coloring by statistics is then used to evaluate docking poses of new compounds. The bromodomain-containing protein 4 – cereblon complex (BRD4-CBRN) and its degrader dBET23 are used as an example.

Discngine’s 3decision team is partnering up with Nanome to bring a new dimension to structural analysis. With 3decision in VR, users will be able to entirely exploit the structural knowledge stored in 3decision in a new and advanced way to accelerate drug-design processes.

Manuel Cases Thomas, a Medicinal chemistry consultant and director at Senechaem was looking for a solution to help him use the full potential of data at hand and generate new design ideas. In this interview, he shares how 3decision® makes a difference in his daily work: from a scientific need to the impact on design ideas and successful project outcomes.

I found my way to quickly learn new software: by validating its features. In this article, I am presenting the retrospective analysis of the detection of BCR-ABL1 allosteric binding site using the 3decision Pocket Explorer feature.

The updated 3decision® version has some important new features for cross-team collaboration and structure-based drug design project management. A lot of improvements are made on the structure visualization UI as well.

For the third time, Discngine is ranked among the TOP500 fastest-growing companies in France!
We would like to thank all of our customers for their trust which made this accomplishment possible.

We are very happy about this result which for us confirms the relevance of our products and services but also validates our organizational model…