Our Biologics Solution Lead, Méliné Simsir, has compiled insights from four recent antibody conferences she has attended, bringing together perspectives from experts across the community.

During lead optimization, SAR analysis drives compound design, while patent data provides context on prior art. These perspectives are often reviewed separately, making early decisions harder. This article looks at how bringing them together in a single workflow with tools such as Discngine Ideation Analytics, reduces rework and guides more confident design choices.

Manual structure-activity relationship (SAR) reporting is a time-consuming, tedious, and repetitive task.

To regain time from data wrangling, Discngine has developed Ideation Analytics- an automated platform for SAR reporting and analysis.

With the recent release of TIBCO Spotfire 12.0 LTS, we are glad to announce the availability of the Discngine Connector 5.8 for Spotfire and Pipeline Pilot. This new release is fully compatible with all the supported LTS versions of Spotfire (10.10, 11.4 and 12.0) and Pipeline Pilot (2022)

If you are frequently using Spotfire and KNIME you might need to jump from one tool to another all the time. In this use case, we are showing how you can do it efficiently with the Discngine connector.

Introducing the Spotfire Web Application for KNIME (a.k.a. SWAK), a Discngine-built connector between two widely used tools in data analysis: KNIME and TIBCO Spotfire®.

Méliné is showing how simple it is to visualize a dataset’s chemical space by building a KNIME workflow projecting the dataset onto the chemical space, before visualizing it efficiently with TIBCO Spotfire® through the SWAK!

The purpose of this article is to illustrate how to apply some of 3decision’s features in scientific research. For this use case, the 3decision Subpocket Similarity Search is used to suggest modifications for the optimization of a small- molecule PROTAC. The Protein-Ligand interaction coloring by statistics is then used to evaluate docking poses of new compounds. The bromodomain-containing protein 4 – cereblon complex (BRD4-CBRN) and its degrader dBET23 are used as an example.

I found my way to quickly learn new software: by validating its features. In this article, I am presenting the retrospective analysis of the detection of BCR-ABL1 allosteric binding site using the 3decision Pocket Explorer feature.

The updated 3decision® version has some important new features for cross-team collaboration and structure-based drug design project management. A lot of improvements are made on the structure visualization UI as well.